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Targets Recommended: Calcium Channel Wnt/beta-catenin

5

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T2003 ISX-9

Isoxazole 9,Isoxazole 9 (ISX-9)

Calcium Channel; Wnt/beta-catenin Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells
ISX-9 (Isoxazole 9) 是一种神经干细胞分化的有效诱导剂,可诱导 Notch 激活的心外膜衍生细胞(NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入,并增加 NeuroD 表达。
T23782 Benzolamide

CL-11366,W 1803,CL 11366,CL11366,苯唑拉胺,W-1803

Carbonic Anhydrase Metabolism
Benzolamide (CL 11366) 是碳酸酐酶 (CA) 抑制剂,抑制hCA I(Ki:15 nM)、hCA II(Ki:9 nM)、EcoCAγ(Ki:94 nM)、VchCAγ(Ki:78 nM)、CAS3(Ki:54 nM)。它可用于研究青光眼和癫痫。
T63731 Carbonic anhydrase inhibitor 9

Carbonic anhydrase inhibitor 9 是碳酸酐酶 (CA) 的有效抑制剂,能够作用于 hCA II (Ki: 56.4 nM) 和 IX (Ki: 56.9 nM),表现出抗增殖效果。
T69383 NBI-42902

NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm). Tritiated NBI-42902 binds with high affinity (K(d) = 0.19 nm) to a single class of binding sites and can be displaced by a range of peptide and nonpeptide GnRH receptor ligands. In vitro experiments demonstrate that NBI-42902 is a potent functional, competitive antagonist of GnRH stimulated IP accumulation, Ca(2+) flux, and ERK1/2 activation. It did not stimulate histamine release from rat...
T37847 Zonisamide-13C2,15N

Zonisamide-13C2,15N

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

化合物

ISX-9
Cat.No: T2003
Synonym: Isoxazole 9,Isoxazole 9 (ISX-9)
Target: Calcium Channel, Wnt/beta-catenin
Benzolamide
Cat.No: T23782
Synonym: CL-11366,W 1803,CL 11366,CL11366,苯唑拉胺,W-1803
Target: Carbonic Anhydrase
Carbonic anhydrase inhibitor 9
Cat.No: T63731
Synonym:
Target:
NBI-42902
Cat.No: T69383
Synonym:
Target:
Zonisamide-13C2,15N
Cat.No: T37847
Synonym: Zonisamide-13C2,15N
Target:
Cat. No. Product Name Target Signaling Pathways
T75670 Lacto-N-fucopentaose II

Lacto-N-fucopentaose II (LNFP II)作为人Lewis血型决定因子的半抗原,其单唾液神经节苷/糖脂以及唾液酰衍生物CA 19-9,都是胆胰恶性肿瘤中的分子肿瘤标记物(TM)。

天然产物

Lacto-N-fucopentaose II
Cat.No: T75670
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPK-00524 CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)

CAIX,CA9,P54/58N,RCC,G250,EC 4.2....

Cynomolgus HEK293 Cells
CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...
TMPK-00283 CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)

RCC,EC 4.2.1.1,CA9,P54/58N,MN,CA-...

Human HEK293 Cells
CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The...
TMPJ-00283 Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated

G250,P54/58N,Carbonic Anhydrase IX,CA9...

Human HEK293 Cells
Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA9 is a transmembrane enzyme expressed primarily in carcinoma cells. It is one of the best markers for hypoxia and for RCC...
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His)

VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...

Human HEK293 Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698 VEGF121b Protein, Human, Recombinant

MVCD1,VEGF,VPF,vascular endothelial growth factor A

Human HEK293 Cells
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005 YAP1 Protein, Human, Recombinant (Isoform 9, His)

YAP1-2delta

Human P. pastoris (Yeast)
YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPK-00825 VEGF121 Protein, Human, Recombinant (His & Avi)

VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826 VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268 Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

NRCAML,neurofascin,NF

Human HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

重组蛋白

CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00524
Species: Cynomolgus
Expression System: HEK293 Cells
CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00283
Species: Human
Expression System: HEK293 Cells
Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated
Cat.No: TMPJ-00283
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00865
Species: Human
Expression System: HEK293 Cells
VEGF121b Protein, Human, Recombinant
Cat.No: TMPY-03698
Species: Human
Expression System: HEK293 Cells
YAP1 Protein, Human, Recombinant (Isoform 9, His)
Cat.No: TMPH-00005
Species: Human
Expression System: P. pastoris (Yeast)
VEGF121 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00825
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00826
Species: Human
Expression System: HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05268
Species: Human
Expression System: HEK293 Cells
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